Clinical Research
- Manitz, J., Gerhold-Ay, A., Kieslich, P., Shah, P., Mrowiec, T., and Tyroller, K. (2023).
Avelumab first-line maintenance in advanced urothelial carcinoma: a complete screening for prognostic and predictive factors using machine learning in the JAVELIN Bladder 100 phase 3 trial.
In preparation.
- Sabanés Bové, D., Seibold, H., Boulesteix, A.-L., Manitz, J., Gasparini, A., Guünhan, B.K., Boix, O., Schüler, A., Fillinger, S., Nahnsen, S., Jacob, A.E., Jaki, T. (2023).
Improving Software Engineering in Biostatistics: Challenges and Opportunities
In preparation.
- Manitz, J., Nicholls, A., Gotti, M., Kelkhoff, D., Clark, A., Palukuru, U.P. and Taylor, L. (2022).
Risk Assessment of R Packages: Learnings and Reflections.
ASA Biopharmaceutical Report. Fall 2022.
- Manitz, J., Kan‐Dobrosky, N., Buchner, H., Casadebaig, M.L., Degtyarev, E., Dey, J., Haddad, V., Jie, F., Martin, E., Mo, M. and Rufibach, K. (2022).
Estimands for overall survival in clinical trials with treatment switching in oncology.
Pharmaceutical Statistics, 21(1), 150-162.
- Manitz, J., D'Angelo, S. P., Apolo, A. B., Eggleton, S. P., Bajars, M., Bohnsack, O., & Gulley, J. L. (2022).
Comparison of tumor assessments using RECIST 1.1 and irRECIST, and association with overall survival.
Journal for Immunotherapy of Cancer, 10(2).
- Terranova, N., French, J., Dai, H., Wiens, M., Khandelwal, A., Ruiz-Garcia, A., Manitz, J., von Heydebreck, A., Ruisi, M., Chin, K. and Girard, P. (2022).
Pharmacometric modeling and machine learning analyses of prognostic and predictive factors in the JAVELIN Gastric 100 phase III trial of avelumab.
CPT: Pharmacometrics & Systems Pharmacology, 11(3), 333-347.
- Hrinczenko, B., Iannotti, N., Goel, S., Spigel, D., Safran, H., Taylor, M.H., Bennouna, J., Wong, D.J., Kelly, K., Verschraegen, C. and Bajars, M (2022).
Long-term avelumab in advanced non-small-cell lung cancer: summaries and post hoc analyses from JAVELIN Solid Tumor.
Future Oncology, 18(11), 1333-1342.
- Park, K., Özgüroğlu, M., Vansteenkiste, J., Spigel, D., Yang, J.C.H., Bajars, M., Ruisi, M., Manitz, J. and Barlesi, F. (2021).
Impact of subsequent immune checkpoint inhibitor treatment on overall survival with avelumab vs docetaxel in platinum-treated advanced NSCLC: Post hoc analyses from the phase 3 JAVELIN Lung 200 trial.
Lung Cancer, 154, 92-98.
- Kelly, K., Manitz, J., Patel, M.R., D’Angelo, S.P., Apolo, A.B., Rajan, A., Kasturi, V., Speit, I., Bajars, M., Warth, J. and Gulley, J.L. (2020).
Efficacy and immune-related adverse event associations in avelumab-treated patients.
Journal for Immunotherapy of Cancer, 8(2).
- Apolo, A. B., Ellerton, J. A., Infante, J. R., Agrawal, M., Gordon, M. S., Aljumaily, R., Gourdin, T., Dirix, L., Lee, K. W., Taylor, M. H., Schöffski, P., Wang, D., Ravaud, A., Manitz, J., Pennock, G., Ruisi, M., Gulley, J. L., & Patel, M. R. (2020).
Avelumab as second-line therapy for metastatic, platinum-treated urothelial carcinoma in the phase Ib JAVELIN Solid Tumor study: 2-year updated efficacy and safety analysis.
Journal for Immunotherapy of Cancer, 8(2), e001246.
- Sonpavde, G., Manitz, J., Gao, C., Tayama, D., Kaiser, C., Hennessy, D., Makari, D., Gupta, A., Abdullah, S.E., Niegisch, G. and Rosenberg, J.E. (2020).
Five-factor prognostic model for survival of post-platinum patients with metastatic urothelial carcinoma receiving PD-L1 inhibitors.
The Journal of Urology, pp.10-1097.
Statistical Methodology
- Li, J., Manitz, J., Bertuzzo, E. and Kolaczyk, E.D. (2021): Sensor-based localization of epidemic sources on human mobility networks. PLOS Computational Biology, 17(1), p.e1008545.
- S. Friedrichs, J. Manitz, P. Burger, C.I. Amos, A. Risch, J. Chang-Claude, H.E. Wichmann, T. Kneib, H. Bickeböller (2017): Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies. Computational and Mathematical Methods in Medicine.
- J. Manitz, J. Harbering, M. Schmidt, T. Kneib, and A. Schöbel (2017): Source Estimation for Propagation Processes on Complex Networks with an Application to Delays in Public Transportation Systems. Journal of Royal Statistical Society C (Applied Statistics), 66: 521–536.
- M. Tahden, J. Manitz, K. Baumgardt, G. Fell, T. Kneib, G. Hegasy (2016): Epidemiological and Ecological Characterization of the EHEC O104:H4 Outbreak in Hamburg, Germany, 2011. PLoS ONE 11(10): e0164508.
- J. Manitz, J. Harbering, M. Schmidt, T. Kneib, and A. Schöbel (2014): Network-based Source Detection: From Infectious Disease Spreading to Train Delay Propagation. Proceedings of the 29th International Workshop on Statistical Modelling. Volume 1. pp. 201-205.
- S. Freytag , J. Manitz, M. Schlather, T. Kneib, C. I. Amos, A. Risch, J. Chang-Claude, J. Heinrich, and H. Bickeböller (2013): A Network-Based Kernel Machine Test for the Identification of Risk Pathways in Genome-Wide Association Studies. Human Heredity, 76(2), pp. 64-75.
Shared first co-auhtorship.
- J. Manitz, T. Kneib, M. Schlather, D. Helbing, and D. Brockmann (2014): Origin Detection during food-borne Disease Outbreaks - A case study 2011 EHEC/HUS Outbreak in Germany. PLOS Currents Outbreaks. Edition 1. pp. 1-31.
- J. Manitz, and T. Kneib (2013): Model-based source estimation during foodborne disease outbreaks. Proceedings of the 28th International Workshop on Statistical Modelling. 2013. pp. 263-267.
- J. Manitz, and M. Höhle (2013): Bayesian model algorithm for monitoring reported cases of campylobacteriosis in Germany. Biometrical Journal, 55(4), pp. 509–526.
Consulting
- A. Macann, F. Fauzi, J. Simpson, G. Sasso, H. Krawitz, C. Fraser-Browne, J. Manitz, A. Raith (2017): Humidification mitigates acute mucosal toxicity during radiotherapy when factoring volumetric parameters. Trans Tasman Radiation Oncology Group (TROG) RadioHUM 07.03 substudy. Oral Oncology, Volume 75, 2017, Pages 75-80.
- A. Schwarzer, S. Bergmann, J. Manitz, H. Küchenhoff, M. Erhard, and E. Rauch (2016): Behavioural studies on the use of open water basins by American mink (Neovison vison). Journal of Veterinary Behavior: Clinical Applications and Research.
- N. Hoke, M. Harbeck, B. Heinz, C. Weber, J. Burger, J. Manitz, G. Grupe (2011). Fluorescence of bone cross sections as a screening tool for bones preceding archaeometric analyses. In: G. Grupe, G. McGlynn and J. Peters (eds.): Archaeobiodiversity. A European perspective.
- S. Schorn, K. Pfister, H. Reulen, M. Mahling, J. Manitz, C. Thiel, and C. Silaghi (2011): Prevalence of Anaplasma phagocytophilum in Ixodes ricinus in Bavarian public parks, Germany. Ticks and Tick-borne Diseases, 2(4), pp. 196-203.
- K. Hermelink, H. Küchenhoff, M. Untch, I. Bauerfeind, M. P. Lux, M. Bühner, J. Manitz, V. Fensterer, and K. Münzel (2010): Two different sides of ‘chemobrain’: determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study. Psycho-Oncology, 19, pp. 1321-1328.
- Y. Ardelt, Y. Kim, M. Köbler, J. Xue, J. Manitz (2009). Sentence mood effects in Chinese, French and Korean: an empirical study. Proceedings of young linguists’ meeting in Poznán conference.
Theses
